Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Zinc (as Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
8
We explored the impact of zinc on heart attack recovery, particularly focusing on how zinc deficiency affects heart cells during ischemia/reperfusion (I/R) injury. The study highlighted that when zinc levels drop, a protein known as PIAS3 is quickly degraded. This degradation helps activate another protein called STAT3, which plays a key role in encouraging the expression of zinc transporter genes. These transporters are vital in regulating zinc levels within heart cells.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
Read More
8
We investigated the connection between serum zinc levels and the risk of heart failure following a myocardial infarction, commonly known as a heart attack. In our study, we focused on 243 patients who were divided based on their zinc levels at the time of their hospital admission. Those with lower zinc levels (below 66 µg/dL) numbered 111, while 132 patients had higher zinc levels.
Throughout an average follow-up of about two years, we observed that 12 of the patients were readmitted due to heart failure. Notably, 10 of these cases were from the low zinc group, highlighting a concerning trend. The results indicated that having lower serum zinc levels significantly increased the likelihood of being readmitted for heart failure, with a hazard ratio of 15.7 when compared to those with higher zinc levels.
This finding suggests a potential risk factor linked to low zinc concentrations following a heart attack. Our analysis indicates that maintaining adequate zinc levels could be crucial for heart health post-myocardial infarction, but further research is necessary to confirm these results and determine the potential benefits of zinc treatment.
Throughout an average follow-up of about two years, we observed that 12 of the patients were readmitted due to heart failure. Notably, 10 of these cases were from the low zinc group, highlighting a concerning trend. The results indicated that having lower serum zinc levels significantly increased the likelihood of being readmitted for heart failure, with a hazard ratio of 15.7 when compared to those with higher zinc levels.
This finding suggests a potential risk factor linked to low zinc concentrations following a heart attack. Our analysis indicates that maintaining adequate zinc levels could be crucial for heart health post-myocardial infarction, but further research is necessary to confirm these results and determine the potential benefits of zinc treatment.
Read More
Most Useful Reviews
6
Positive heart effect
41 people found this helpful
The last time I purchased this supplement in gelatin capsules, I couldn't immediately discern the difference. I take it to support my heart, and I appreciate its effects. When I attempted to increase the dosage, my heartbeat became somewhat unsettled. I'm grateful to IHERB and all those who contribute reviews; it significantly aids in supplement selection, as doctors aren't always reliably knowledgeable.
Read More
7.5
Essential heart mineral
Zinc is crucial for heart, liver, and nerve health, as well as every cell and organ in the body. It acts as a superb antioxidant, boosting immunity and positively influencing various diseases. Its benefits extend to strengthening hair, and a deficiency leads to numerous health issues. The quantity, quality, and ingredients are all commendable.
Read More
7.5
Excellent for heart
The quality of all iHerb products is outstanding! They contain all-natural ingredients, are very beneficial for health, have convenient packaging, are suitable for all ages, and are made solely from clean fish. This reduces inflammation and is excellent for the heart.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
- All Researches
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
9
We investigated how zinc contributes to recovery after a heart attack, specifically focusing on its role in promoting heart health. The study centered on a new bioceramic material made from zinc and silicon oxide, which releases bioactive elements that work together to support heart cell function and reduce damage.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Read More
8
The research examined how zinc interacts with atrial natriuretic peptide (ANP) to offer protection during heart attacks, specifically in situations involving ischemia and reperfusion. Through studies conducted in both isolated rat hearts and mouse models, we investigated whether ANP could modify zinc levels to help protect heart tissue from damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
Read More
8
We aimed to understand how dietary zinc intake influences the risk of heart attacks, along with other cardiovascular diseases (CVDs). Utilizing data from a National Health and Nutrition Examination Survey spanning 2005 to 2018, we looked at various ranges of zinc consumption among participants.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
Read More
8
We explored the impact of zinc on heart attack recovery, particularly focusing on how zinc deficiency affects heart cells during ischemia/reperfusion (I/R) injury. The study highlighted that when zinc levels drop, a protein known as PIAS3 is quickly degraded. This degradation helps activate another protein called STAT3, which plays a key role in encouraging the expression of zinc transporter genes. These transporters are vital in regulating zinc levels within heart cells.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
6
Positive heart effect
41 people found this helpful
The last time I purchased this supplement in gelatin capsules, I couldn't immediately discern the difference. I take it to support my heart, and I appreciate its effects. When I attempted to increase the dosage, my heartbeat became somewhat unsettled. I'm grateful to IHERB and all those who contribute reviews; it significantly aids in supplement selection, as doctors aren't always reliably knowledgeable.
Read More
7.5
Essential heart mineral
Zinc is crucial for heart, liver, and nerve health, as well as every cell and organ in the body. It acts as a superb antioxidant, boosting immunity and positively influencing various diseases. Its benefits extend to strengthening hair, and a deficiency leads to numerous health issues. The quantity, quality, and ingredients are all commendable.
Read More
7.5
Excellent for heart
The quality of all iHerb products is outstanding! They contain all-natural ingredients, are very beneficial for health, have convenient packaging, are suitable for all ages, and are made solely from clean fish. This reduces inflammation and is excellent for the heart.
Read More
Frequently Asked Questions
6
Positive heart effect
41 people found this helpful
The last time I purchased this supplement in gelatin capsules, I couldn't immediately discern the difference. I take it to support my heart, and I appreciate its effects. When I attempted to increase the dosage, my heartbeat became somewhat unsettled. I'm grateful to IHERB and all those who contribute reviews; it significantly aids in supplement selection, as doctors aren't always reliably knowledgeable.
7.5
Excellent for heart
The quality of all iHerb products is outstanding! They contain all-natural ingredients, are very beneficial for health, have convenient packaging, are suitable for all ages, and are made solely from clean fish. This reduces inflammation and is excellent for the heart.
7.5
Essential heart mineral
Zinc is crucial for heart, liver, and nerve health, as well as every cell and organ in the body. It acts as a superb antioxidant, boosting immunity and positively influencing various diseases. Its benefits extend to strengthening hair, and a deficiency leads to numerous health issues. The quantity, quality, and ingredients are all commendable.
8
We aimed to understand how dietary zinc intake influences the risk of heart attacks, along with other cardiovascular diseases (CVDs). Utilizing data from a National Health and Nutrition Examination Survey spanning 2005 to 2018, we looked at various ranges of zinc consumption among participants.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
8
The research examined how zinc interacts with atrial natriuretic peptide (ANP) to offer protection during heart attacks, specifically in situations involving ischemia and reperfusion. Through studies conducted in both isolated rat hearts and mouse models, we investigated whether ANP could modify zinc levels to help protect heart tissue from damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
8
We explored the potential of a zinc-based hydrogel designed to address the damaging effects of heart attacks, specifically focusing on the harmful rise in reactive oxygen species (ROS) that occurs in the aftermath. These ROS can lead to heart cell death, inflammation, and complications in the healing process. By using a hydrogel, we aimed to provide both support and an active solution to combat this issue.
The hydrogel, developed from ZIF-8, combines properties that mimic key antioxidant enzymes in the body, effectively reducing excess ROS in the affected heart area. This action is crucial because too much ROS can prolong damage and hinder recovery. Interestingly, the hydrogel also influences immune cells, encouraging them to adopt a healing role and support the regeneration of heart tissue.
A notable feature of this hydrogel is its gradual release of zinc ions, which are essential for repairing heart tissues. As the hydrogel breaks down, these zinc ions support cellular function and improve overall heart performance after a heart attack. Therefore, this innovative approach not only provides a protective element against oxidative stress but also supplies necessary nutrients for healing.
In summary, our findings show that a multifunctional hydrogel with zinc can significantly help in managing the effects of myocardial infarction. This study opens new avenues for treating heart attack by not only restoring blood flow but also by addressing the oxidative stress that complicates recovery.
The hydrogel, developed from ZIF-8, combines properties that mimic key antioxidant enzymes in the body, effectively reducing excess ROS in the affected heart area. This action is crucial because too much ROS can prolong damage and hinder recovery. Interestingly, the hydrogel also influences immune cells, encouraging them to adopt a healing role and support the regeneration of heart tissue.
A notable feature of this hydrogel is its gradual release of zinc ions, which are essential for repairing heart tissues. As the hydrogel breaks down, these zinc ions support cellular function and improve overall heart performance after a heart attack. Therefore, this innovative approach not only provides a protective element against oxidative stress but also supplies necessary nutrients for healing.
In summary, our findings show that a multifunctional hydrogel with zinc can significantly help in managing the effects of myocardial infarction. This study opens new avenues for treating heart attack by not only restoring blood flow but also by addressing the oxidative stress that complicates recovery.
References
- Ma YT, Laga T, Zhong CN, Zhuang BQ, Quan HL, et al. ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. Curr Med Sci. 2025;45:35. doi:10.1007/s11596-025-00019-1
- Mohamed ATAE, Ragheb MA, Shehata MR, Mohamed AS. In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production. J Trace Elem Med Biol. 2024;86:127516. doi:10.1016/j.jtemb.2024.127516
- Zhang W, Li Y, Zheng K, Li Y, Yang H. Nonlinear associations between dietary zinc intake and cardiovascular disease risk, a National cross-sectional study based on the NHANES 2005-2018. Prev Med Rep. 2024;45:102830. doi:10.1016/j.pmedr.2024.102830
- Wang S, Wang H, Li L, Niu P, Yin Z, et al. Long-term inhaling ultrafine zinc particles increases cardiac wall stresses elevated by myocardial infarction. Biomed Eng Online. 2024;23:78. doi:10.1186/s12938-024-01275-3
- Zhao H, Liu D, Sun S, Yu J, Bian X, et al. PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury. Free Radic Biol Med. 2024;221:188. doi:10.1016/j.freeradbiomed.2024.05.025
- Tanita A, Namiuchi S, Onodera K, Sunamura S, Ogata T, et al. Serum zinc concentration in patients with myocardial infarction: a retrospective study. BMC Cardiovasc Disord. 2024;24:107. doi:10.1186/s12872-024-03776-4
- Zhong Y, Yang Y, Xu Y, Qian B, Huang S, et al. Design of a Zn-based nanozyme injectable multifunctional hydrogel with ROS scavenging activity for myocardial infarction therapy. Acta Biomater. 2024;177:62. doi:10.1016/j.actbio.2024.01.015
- Zhang Y, Li X, Zhang Z, Li H, Chen D, et al. Zn SiO Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction. Adv Healthc Mater. 2023;12:e2203365. doi:10.1002/adhm.202203365
- Huo Y, Li L. Long-Term Inhalation of Ultrafine Zinc Particles Deteriorated Cardiac and Cardiovascular Functions in Rats of Myocardial Infarction. Front Physiol. 2022;13:921764. doi:10.3389/fphys.2022.921764
